The association of “Neurofibromatosis-1, congenital pseudarthrosis of the Tibia and type 1 DM” report of two cases and literature review

Neurofibromatosis type 1 (NF1) is a relatively common disorder and is typically diagnosed clinically. NF1 is commonly associated with different autoimmune diseases. The association between NF1 and Type 1DM is rarely reported in the literature. We are presenting the first report of two children who are known to have Neurofibromatosis-1 and congenital pseudarthrosis of the tibia and during their treatment, they developed type 1 DM. Neurofibromatosis-1 is a multi-systemic disorder, and its management involves various medical and surgical specialties. Before embarking on major limb reconstruction for CPT, the Orthopaedic surgeon is requested to consider other systemic involvements. A high suspicion index should draw the attention of the treating surgeon in case the child develops any symptoms or signs suggestive of any systemic disorder.