Advances in Imaging Techniques for Retinoblastoma with Subretinal Seeding

Retinoblastoma is a rare and highly malignant intraocular tumor primarily affecting young children. Subretinal seeding, specifically Type D, indicates an advanced stage of retinoblastoma with a high risk of metastasis and a poor prognosis. We present a case of a 4-year-old girl who presented with leukocoria, vision loss, and painless redness in her left eye. Examination of the posterior segment revealed a total retinal detachment and abnormal, tortuous retinal vessels in the left eye. No visible mass, vitreous seeding, or hemorrhage was observed. B-mode ultrasound confirmed a detached retina. Due to the poor visual prognosis and strong clinical suspicion of malignancy, enucleation was performed. Further histopathological analysis confirmed the diagnosis of diffuse infiltrative retinoblastoma.