Triglyceride-glucose index and colorectal cancer risk and prognosis - a retrospective study

Abstract OBJECTIVE To verify the correlation of triglyceride-glucose index with the incidence of colorectal cancer and to further determine the correlation of triglyceride-glucose index with the prognosis of colorectal cancer, so as to infer whether the TyG index can be predictive of the incidence and prognosis of colorectal cancer. METHODS This is a retrospective study that evaluated the link with TyG index and the incidence and progression of colorectal cancer. We discussed the connection among TyG index and colorectal cancer risk using logistic regression modeling, respectively, by adjusting for covariates such as gender, age, level of alcohol consumption, and level of smoking. We depicted the ROC curve by analyzing and comparing the size of the area under the curve (AUC) of each risk factor.And we analyzed the correlation between TyG index and pathological stage and three-year prognostic outcome of colorectal cancer patients, respectively. RESULTS Among the 609 participants surveyed, the TyG index was significantly higher in patients with colorectal cancer than in those with normal colorectal function (p < 0.001) ).By adjusting for confounders, the OR for TyG index was 2.001 (95% CI 1.367–2.929, p < 0.001). The area under the curve (AUC) for TyG in the ROC curve analysis was 0.584 (95% CI 0.539–0.629, p < 0.001). Furthermore, the TyG index was correlated and analyzed with three-year prognosis of patients with colorectal cancer, and the OR for TyG was 2.123 (95% CI 1.014–4.445, p = 0.046). CONCLUSION TyG index can be one of the predictors of colorectal cancer incidence. Also TyG index can be one of the indicators to predict poor prognosis of colorectal cancer.