FIGURE 3 from Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition

Blockade of β₂-AR blunts the mobilization and expansion of Vγ9Vδ2+ T-cells. A, The physiologic effects of a placebo, β1-AR antagonist (10 mg bisoprolol), or a nonselective β1+β2 antagonist (80 mg, nadolol) on VO₂ (mL/minute), systolic blood pressure (mmHg), HR (bpm), epinephrine (ng/mL), and norepinephrine (ng/mL) during the last minutes of acute exercise (n = 9). The effects of a placebo, β1-AR antagonist, or a nonselective β1+β2 antagonist on the total number of Vγ9Vδ2+ T-cells mobilized with exercise (B) and the ex vivo expansion of Vγ9Vδ2+ T-cells after 14 days with ZOL+IL2 (n = 9; C). Data are represented as mean ± SEM; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001 by repeated measures one-way ANOVA with Bonferroni post hoc test.