A highly enantioselective synthetic method for 3,4-trans-dihydropyrans was developed by the reaction of α-acyl-β-aryl-substituted acrylonitrile and aldehyde catalyzed by diphenylprolinol silyl ether. This is an asymmetric domino reaction via a catalytic Michael reaction/enolization/acetalization.
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Hayashi et al. (2024) studied this question.
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