Highly Scalable and Robust Ribbon-like Coordination Polymer as Green Catalyst for Hantzsch Condensation in Synthesis of DHPs and Bioactive Drug Molecule

Ribbon-like coordination polymers (CP) represents a highly unexplored innovative class of metal-coordination network. Herein, we have developed a highly scalable and chemically robust (pH=3-10 stable) ribbon-like CP [{Cu(Pim)(L)(H2O).H2O}]n (1) following a complete environment-friendly green synthesis route. Considering the presence of surface flanked labile coordinated water molecules and their appealing correlation with one-dimensional structural characteristics, such sort of ribbon-like CP was explored for the first time as excellent heterogeneous surface catalyst for largely unexplored three-component Hantzsch condensation for synthesis of different classes of dihydropyridine (DHP). Moreover, 1 is employed to synthesize bio-responsive drug 'Ethidine' (possessing high anti-oxidant and anticarcinogenic properties) characterized with Single Crystal X-ray Diffraction (SCXRD) analysis. Several DHP-based products are also analysed through in-depth SCXRD analysis. This report inaugurates the usage of a Cu(II) based ribbon-like CPs as heterogeneous surface catalyst following environmentally benign manner for synthesis of bioactive DHPs and Drugs.