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May 10, 2024PhytomedicineOpen Access

Forsythoside A regulates pulmonary fibrosis by inhibiting endothelial-to-mesenchymal transition and lung fibroblast proliferation via the PTPRB signaling

Qinqin Zhang Beibei Zhang Fan Yang Yingbo Hu Ruyi Fan Mengya Wang Suiqing Chen

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Abstract

Pulmonary fibrosis (PF) is an end-stage change in many interstitial lung diseases, whereas no proven effective anti-pulmonary fibrotic treatments. Forsythoside A (FA) derived from Forsythia suspensa (Thunb.) Vahl, has been found to possess lung-protective effect. However, studies on its anti-pulmonary fibrosis effect are limited and its mechanism of action remains unknown.

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Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e6a9d7b6db64358762ce2e https://doi.org/10.1016/j.phymed.2024.155715

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