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Hot thyroid nodules are mostly benign and rarely show a malignant nature. Here we present the case of a 45-year-old man with a hypercaptant but ultrasound suspicious nodule; he underwent fine needle aspiration (FNA) and subsequent thyroidectomy. Pathology revealed a papillary thyroid carcinoma (PTC) with focal tall cell features, positivity to BRAF V600E and focal hyperspression of p53. A multidisciplinary clinicopathological approach is crucial for the correct diagnosis.
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Lai et al. (2024) studied this question.
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