Inadvertent Massive overdose of Isoproterenol During Electrophysiology Study Treated Successfully with Intravenous Metoprolol: Two Case Reports

Isoproterenol is a beta-adrenergic agonist used during electrophysiological studies (EPS) to enhance their sensitivity. Even though it is uncommon, medication overdose errors can occur due to different causes and may lead to life-threatening situations. In this article, we report two cases of inadvertent massive overdoses of isoproterenol during EPS. Both incidents resulted in characteristic symptoms like anxiety and palpitations, however, were successfully reversed with metoprolol administration. The aim is to emphasize the need for robust safety measures and clear communication within the healthcare team. Although both patients tolerated the overdose well, the outcome for severe complications, particularly in patients with underlying heart conditions, might not be favourable.