Systemic iron overload: Review of pathophysiology and clinical-radiological diagnostic approach

Systemic iron overload is a condition that carries significant implications for health, making it crucial to understand its pathophysiology and the precise clinical and radiological diagnostic methods. This article comprehensively reviews the pathophysiology of iron metabolism, highlighting its crucial role in multiple cellular processes and the regulatory mechanisms that maintain its balance in the body. Furthermore, the diagnostic approach to iron overload is analyzed in detail, reviewing the role of various imaging techniques; highlighting magnetic resonance imaging as a method to develop an accurate and non-invasive assessment of iron load in various tissues.