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May 8, 2024Drug Metabolism and Disposition

After 50 Years of Hepatic Clearance Models, Where Should We Go from Here? Improvements and Implications for Physiologically Based Pharmacokinetic Modeling

K. Sandy Pang Weijia Ivy Lu Gerard J. Mulder

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Abstract

There is overwhelming preference for application of the unphysiologic, well-stirred model (WSM) over the parallel tube model (PTM) and dispersion model (DM) to predict hepatic drug clearance,

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Cite This Study

Pang et al. (2024) studied this question.

synapsesocial.com/papers/68e6b135b6db6435876327af https://doi.org/10.1124/dmd.124.001649

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