Objectives: In this research paper, an investigation has been made to assess the simultaneous effect of a solubility enhancement approach i.e. hydrotropy on the solubility and apparent permeability of piroxicam. The solubility of piroxicam (PRX) a BCS (biopharmaceutics classification system) class II drug has been increased using a mixed hydrotropy approach. This study is based on identifying the pattern of solubility-permeability interplay and confirming whether every solubility gain results in a concomitant decrease in permeability or permeability remains unaffected.
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Nainwal et al. (2024) studied this question.
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