In vitro evaluation demonstrates antitumor and antimicrobial actions of Fusarium metabolites in MCF-7 cancer and microbial cells, indicating novel therapeutic potential.
To evaluate the biological activities of secondary metabolites obtained from Fusarium species. The secondary metabolites of Fusarium oxysporum showed a proliferative effect on MCF-7 cells. The secondary metabolites of Fusarium solani reduced the viability of the MCF-7 cell in 48 hours. The metabolites of both fungi showed significant antibacterial activity (p<0.0010) in E. coli strains at all concentrations. F.oxysporum and solani significantly inhibited S. aureus at all concentrations within 24h. F. oxysporum metabolites significantly reduced C. albicans at all concentrations within 24h. The secondary metabolites of Fusarium solani significantly (p<0.0001) reduced the viability of C. albicans at all concentrations. There are compounds in Fusarium solani with antitumor and antimicrobial properties.
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