Correlation analysis of peripheral platelet markers and disease phenotypes in Alzheimer's disease

INTRODUCTION Platelets serve as the primary peripheral reservoir of amyloid beta (Aβ). However, there is limited research on platelet markers in routine blood examinations, particularly with regard to the large platelet ratio (P‐LCR) in Alzheimer's disease (AD). METHODS This study included 512 AD patients and 205 healthy controls (HCs). Platelet markers and apolipoprotein E ( APOE ) 4 status were assessed in all participants. RESULTS The study revealed that P‐LCR was significantly elevated in AD patients compared to HCs. In AD patients carrying APOE 4, P‐LCR significantly negatively correlated with Montreal Cognitive Assessment scores. There was an observed increasing trend in the rate of change in P‐LCR with disease progression. Binary logistic regression analysis indicated that P‐LCR may constitute a risk factor for AD, after adjusting for age, sex, APOE 4, and body mass index. DISCUSSION P‐LCR is associated with disease severity in AD patients carrying APOE 4. P‐LCR may be a promising marker to reflect platelet activity in AD patients. Highlights P‐LCR significantly negatively correlated with MoCA scores in AD patients with APOE 4. The rate of change in P‐LCR showed an increasing trend with disease progression. P‐LCR may be a risk factor for AD.