Why the study?
Do lipoprotein lipase (LPL) variants 447Ter and 291Ser affect the risk of Alzheimer's disease?
Population
Caucasian Alzheimer's disease (AD) patients and elderly normal (N) subjects
Comparison
Lipoprotein lipase (LPL) alleles 447Ter and 291Ser vs Elderly normal subjects
Design
Case-control
Authors
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No significant LPL variant–AD link detected; leaves open any subtle effects for larger studies.
Do lipoprotein lipase (LPL) variants 447Ter and 291Ser affect the risk of Alzheimer's disease?
There are non-significant trends suggesting a putative protective effect of the LPL 447Ter allele and a causative effect of the 291Ser allele on Alzheimer's disease risk and pathology.
Baum et al. (2000) studied this question.
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