Why the study?
Is the LPL Ser447Ter polymorphism associated with a decreased risk of brain infarction and coronary artery disease in a very elderly population?
Population
252 very elderly individuals derived from the prospective, population-based Vantaa 85+ study
Comparison
Presence of lipoprotein lipase gene polymorphisms vs Absence of the respective LPL gene polymorphisms
Design
Case-control
Authors
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LPL Ter447 supports lower infarct and CAD risk in very elderly; hypothesis-generating and requires prospective confirmation before practice implications.
Is the LPL Ser447Ter polymorphism associated with a decreased risk of brain infarction and coronary artery disease in a very elderly population?
The Ter447 variant of the LPL gene is associated with a decreased risk of brain infarction and severe coronary artery disease, alongside a favorable lipid profile, in a very elderly population.
Myllykangas et al. (2001) studied this question.
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