Why the study?
Are LPL gene polymorphisms (HindIII, PvuII, and Ser447Ter) associated with altered lipid profiles and coronary artery disease in Saudi patients?
Population
336 Saudi individuals, comprising 226 patients with coronary artery disease (CAD) and 110 controls.
Comparison
Lipoprotein lipase gene polymorphisms vs Controls without coronary artery disease
Design
Case-control
Authors
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Does not support routine LPL genotyping in CAD; hypothesis-generating in Saudi patients and requires prospective validation.
Are LPL gene polymorphisms (HindIII, PvuII, and Ser447Ter) associated with altered lipid profiles and coronary artery disease in Saudi patients?
Specific LPL gene polymorphisms (HindIII TT, PvuII TC, and Ser447Ter CC) are associated with reduced HDL-C levels in Saudi patients with coronary artery disease.
Daoud et al. (2013) studied this question.
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