Why the study?
Are LPL gene polymorphisms associated with the risk of myocardial infarction, severity of atherosclerosis, and fasting plasma lipoprotein concentrations?
Population
1,347 individuals (614 patients with myocardial infarction and 733 controls) from the ECTIM study
Comparison
Presence of LPL gene polymorphisms vs Reference genotypes or absence of the respective…
Design
Case-control
Authors
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No immediate change to MI risk assessment; leaves open whether LPL HindIII variants improve prediction or prevention.
Are LPL gene polymorphisms associated with the risk of myocardial infarction, severity of atherosclerosis, and fasting plasma lipoprotein concentrations?
LPL gene polymorphisms, particularly the HindIII polymorphism, are associated with altered lipoprotein profiles and an increased risk of myocardial infarction.
Jemaa et al. (1996) studied this question.
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