Lipoprotein Lipase Gene Variation Is Associated With a Paternal History of Premature Coronary Artery Disease and Fasting and Postprandial Plasma Triglycerides
Why the study?
Is the LPL H-X447 haplotype associated with a lower risk of premature myocardial infarction and lower plasma triglycerides compared to the H+S447 haplotype?
Population
2,119 subjects from the European Atherosclerosis Research Study from five regions of Europe.
Comparison
LPL gene variation (H-X447 haplotype) vs H+S447 haplotype
Design
Case-control
Authors
Discussion
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Member takes
Implication
No change to clinical MI risk assessment; leaves open whether LPL H-X447 variants causally modify familial cardiovascular risk.
Structured PICO
Is the LPL H-X447 haplotype associated with a lower risk of premature myocardial infarction and lower plasma triglycerides compared to the H+S447 haplotype?
P
Population
2,119 subjects from the European Atherosclerosis Research Study (EARS I: 515 offspring of fathers with premature MI <55 years old and 930 age- and sex-matched controls; EARS II: 332 cases and 342 controls) from five regions of Europe.
I
Intervention
LPL gene variation (H-X447 haplotype)
C
Comparator
H+S447 haplotype
O
Outcome
Paternal history of premature myocardial infarction and fasting/postprandial plasma triglyceride levels
The LPL H-X447 haplotype is associated with a reduced risk of premature myocardial infarction and lower fasting and postprandial triglyceride levels.
Cite This Study
Humphries et al. (1998) studied this question.