Key result
In males, the LPL H-X haplotype was associated with a protective effect against significant angiographically assessed coronary artery disease (OR 0.36; 95% CI 0.13-0.97).
Why the study?
Are variants in the lipoprotein lipase (LPL) gene associated with lipid levels and angiographically assessed coronary atherosclerosis in a southern Brazilian population?
Population
506 individuals of European descent in southern Brazil.
Comparison
Six variants in the lipoprotein lipase gene vs Non-carriers or different haplotypes
Design
Case-control
Authors
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LPL H-X haplotype may lower CAD risk in southern Brazilian males; leaves open replication before any clinical consideration.
Case-Control (n=506)
Are variants in the lipoprotein lipase (LPL) gene associated with lipid levels and angiographically assessed coronary atherosclerosis in a southern Brazilian population?
Effect estimate: OR 0.36 (95% CI 0.13-0.97)
The HindIII and S447X variants in the LPL gene, specifically the H-X haplotype, are associated with lower triglycerides, higher HDL cholesterol, and a protective effect against significant coronary atherosclerosis in southern Brazilian males.
Rios et al. (2003) conducted a case-control in Coronary artery disease (n=506). LPL gene variants (H-X haplotype) vs. H+S haplotype / controls was evaluated on Significant disease (≥ 60% of luminal coronary stenosis) (OR 0.36, 95% CI 0.13-0.97). In males, the LPL H-X haplotype was associated with a protective effect against significant angiographically assessed coronary artery disease (OR 0.36; 95% CI 0.13-0.97).
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