July 1, 2001Stroke
Polymorphism of the Lipoprotein Lipase Gene and Risk of Atherothrombotic Cerebral Infarction in the Japanese
Key result
The Ser447Stop mutation of the LPL gene (CG+GG vs CC genotype) was associated with a lower risk of atherothrombotic cerebral infarction (OR 0.42; 95% CI 0.18-0.99; P=0.046).
Why the study?
Are polymorphisms of the LPL gene associated with the risk of ischemic cerebrovascular disease in a Japanese population?
Study Design
Type
Case-Control (n=354)
Structured PICO
Are polymorphisms of the LPL gene associated with the risk of ischemic cerebrovascular disease in a Japanese population?
P
Population
354 Japanese subjects, comprising 177 patients with ischemic cerebrovascular disease and 177 healthy controls, evaluated for LPL gene polymorphisms.
E
Exposure
Ser447Stop mutation and HindIII/PvuII restriction fragment length polymorphisms of the LPL gene
C
Comparator
Wild-type or other genotypes
O
Outcome
Association with ischemic cerebrovascular disease (CVD) and its clinical subtypeshard clinical
Main Result
Odds Ratio: 0.42 (95% CI 0.18–0.99)
p-value: p=0.046
The Ser447Stop mutation of the LPL gene may serve as a novel genetic marker for a lower risk of atherothrombotic cerebral infarction in the Japanese population.
Authors
Discussion
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Implication
May inform genetic risk models in Japanese cohorts; leaves open prospective validation before any clinical use.
Cite This Study
Shimo-Nakanishi et al. (2001) conducted a case-control in Ischemic cerebrovascular disease (n=354). Ser447Stop mutation of the LPL gene vs. CC genotype (absence of mutation) was evaluated on Atherothrombotic cerebral infarction (OR 0.42, 95% CI 0.18-0.99, p=0.046). The Ser447Stop mutation of the LPL gene (CG+GG vs CC genotype) was associated with a lower risk of atherothrombotic cerebral infarction (OR 0.42; 95% CI 0.18-0.99; P=0.046).