Key result
The LPL HindIII and PvuII polymorphisms were significantly associated with a reduced risk of ischemic stroke (OR 0.80 and OR 0.75, respectively), whereas the Ser447Ter polymorphism showed no significant association.
Why the study?
Do LPL gene polymorphisms (Ser447Ter, HindIII, PvuII) alter the risk of ischemic stroke?
Meta-Analysis
Do LPL gene polymorphisms (Ser447Ter, HindIII, PvuII) alter the risk of ischemic stroke?
Odds Ratio: 0.8 (95% CI 0.71–0.9)
p-value: p=0.0002
The HindIII and PvuII polymorphisms of the LPL gene, but not Ser447Ter, appear to be protective factors against ischemic stroke, particularly in Asian populations.
No takes yet. Share an insight, caveat, or question.
Should not yet alter stroke risk assessment; hypothesis-generating for LPL variants pending prospective validation.
Cao et al. (2018) conducted a meta-analysis in Ischemic stroke. LPL HindIII and PvuII polymorphisms vs. Reference alleles (controls) was evaluated on Risk of ischemic stroke (HindIII allelic model) (OR 0.80, 95% CI 0.71, 0.90, p=0.0002). The LPL HindIII and PvuII polymorphisms were significantly associated with a reduced risk of ischemic stroke (OR 0.80 and OR 0.75, respectively), whereas the Ser447Ter polymorphism showed no significant association.
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