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March 1, 2002Genetic Epidemiology

LPL polymorphism predicts stroke risk in men

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Why the study?

Does the presence of LPL or APOE gene polymorphisms predict the risk of subclinical or clinical stroke in a middle-aged population?

Structured PICO

Does the presence of LPL or APOE gene polymorphisms predict the risk of subclinical or clinical stroke in a middle-aged population?

P

Population

Middle-aged American population from the Atherosclerosis Risk in Communities (ARIC) Study. Subclinical stroke analysis included 197 cases and 200 controls. Clinical ischemic stroke analysis included 218 cases and 964 controls.

I

Intervention

Presence of lipoprotein lipase (LPL) S447X and S291 polymorphisms, and apolipoprotein E (APOE) epsilon2 and epsilon4 polymorphisms

C

Comparator

Absence of these specific genotypes

O

Outcome

Subclinical stroke (determined by cerebral MRI) and incidence of clinical ischemic strokehard clinical

The LPL S447X polymorphism is significantly associated with an increased risk of both subclinical cerebral infarction and incident clinical ischemic stroke in men, independent of traditional lipid levels.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support incorporating LPL genotyping into stroke risk assessment; leaves open causal role and utility beyond traditional factors in men.

Cite This Study

Morrison et al. (2002) studied this question.

synapsesocial.com/papers/6a82c07c0f52607ca18ae51f https://doi.org/10.1002/gepi.0191

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Lipoprotein Lipase Variants D9N and N291S Are Associated With Increased Plasma Triglyceride and Lower High-Density Lipoprotein Cholesterol Concentrationscross-sectional · 1997 · 102 citations
2DNA variants at the LPL gene locus associate with angiographically defined severity of atherosclerosis and serum lipoprotein levels in a Welsh population.case-control · 1994 · 140 citations
3A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease.case-control · 1997 · 114 citations
4G-Protein β3 Subunit and α-Adducin Polymorphisms and Risk of Subclinical and Clinical Strokecase-control · 2001 · 82 citations
5Familial Resemblance of Plasma Lipids, Lipoproteins and Postheparin Lipoprotein and Hepatic Lipases in the HERITAGE Family Studycross-sectional · 1997 · 157 citations