Key result
In subjects with either APOE epsilon2 or epsilon4 alleles, LPL X alleles were significantly associated with increased risk of vascular disease (OR 2.2, p=0.01).
Why the study?
Do APOE exon 4 and LPL S447X polymorphisms affect the risk of acute ischemic stroke and myocardial infarction?
Case-Control (n=816)
Do APOE exon 4 and LPL S447X polymorphisms affect the risk of acute ischemic stroke and myocardial infarction?
Odds Ratio: 2.2
p-value: p=0.01
APOE exon 4 and LPL S447X polymorphisms, and their interactions with sex and smoking, are associated with altered risk of myocardial infarction and ischemic stroke.
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APOE-LPL interactions with sex and smoking may modulate MI and stroke risk; leaves open validation in prospective cohorts.
Baum et al. (2006) conducted a case-control in acute ischemic stroke and myocardial infarction (n=816). APOE exon 4 and LPL S447X polymorphisms vs. Controls was evaluated on Vascular disease in subjects with either APOE epsilon2 or epsilon4 alleles (OR 2.2, p=0.01). In subjects with either APOE epsilon2 or epsilon4 alleles, LPL X alleles were significantly associated with increased risk of vascular disease (OR 2.2, p=0.01).
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