Why the study?
Does the Ser447-Ter mutation of the LPL gene reduce the risk of coronary artery disease in Japanese subjects?
Population
189 Japanese subjects, comprising 93 patients with coronary artery disease and 96 age- and sex-matched…
Comparison
Presence of the Ser447-Ter mutation of the… vs Absence of the Ser447-Ter mutation (CC genotype).
Design
Case-control
Authors
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May support LPL variant as protective against CAD in Japanese; leaves open prospective validation before any clinical use.
Does the Ser447-Ter mutation of the LPL gene reduce the risk of coronary artery disease in Japanese subjects?
The Ser447-Ter mutation of the LPL gene is associated with a favorable lipid profile and may protect against the development of coronary artery disease in the Japanese population.
Sawano et al. (2001) studied this question.
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