June 17, 1997Circulation

Genetic Variant Showing a Positive Interaction With β-Blocking Agents With a Beneficial Influence on Lipoprotein Lipase Activity, HDL Cholesterol, and Triglyceride Levels in Coronary Artery Disease Patients

View Full Paper

Ask AI

Bookmark

Why the study?

Does the LPL Ser447-Stop mutation and its interaction with beta-blockers improve lipid profiles and LPL activity in CAD patients?

Population

820 coronary artery disease (CAD) patients with normal to mildly elevated total and LDL cholesterol levels

Comparison

Presence of the LPL Ser447-Stop allele and use… vs Noncarriers of the LPL Ser447-Stop allele and…

Design

Cross-sectional

Authors

BGBjörn E. GroenemeijerClinical Trial Investigators MHMichael D. HallmanLeiden University PRPaul W.A. ReymerLeiden University

Discussion

Member takes

Implication

Hypothesis-generating for LPL-beta-blocker synergy in CAD; should not change practice without prospective data.

Structured PICO

Does the LPL Ser447-Stop mutation and its interaction with beta-blockers improve lipid profiles and LPL activity in CAD patients?

Population

820 coronary artery disease (CAD) patients with normal to mildly elevated total and LDL cholesterol levels

Intervention

Presence of the LPL Ser447-Stop allele (heterozygotes and homozygotes) and use of beta-blockers

Comparator

Noncarriers of the LPL Ser447-Stop allele and non-use of beta-blockers

Outcome

Postheparin lipoprotein lipase (LPL) activity, hepatic lipase (HL) activity, HDL cholesterol levels, and triglyceride levelssurrogate

The LPL Ser447-Stop mutation is associated with a favorable lipid profile and increased LPL activity in CAD patients, an effect that is enhanced by beta-blocker therapy.

Cite This Study

Groenemeijer et al. (1997) studied this question.

synapsesocial.com/papers/6a7deecd7c193befc433a577 https://doi.org/10.1161/01.cir.95.12.2628

Topics

Coronary artery disease

View Full Paper

Ask AI

Bookmark

Genetic Variant Showing a Positive Interaction With β-Blocking Agents With a Beneficial Influence on Lipoprotein Lipase Activity, HDL Cholesterol, and Triglyceride Levels in Coronary Artery Disease Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Genetic Variant Showing a Positive Interaction With β-Blocking Agents With a Beneficial Influence on Lipoprotein Lipase Activity, HDL Cholesterol, and Triglyceride Levels in Coronary Artery Disease Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider