Why the study?
Do common genetic variants of lipoprotein lipase (serine447-ter and asp9-asn) affect lipid levels or the risk of premature coronary artery disease in Caucasian subjects?
Population
329 Caucasian subjects, including 243 with angiographic features of premature atherosclerosis and 86 controls.
Comparison
Presence of common genetic variants of… vs Absence of these mutations, and control subjects…
Design
Case-control
Authors
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Ser447-Ter may lower triglycerides without altering premature CAD risk; leaves open causal effects in larger cohorts.
Do common genetic variants of lipoprotein lipase (serine447-ter and asp9-asn) affect lipid levels or the risk of premature coronary artery disease in Caucasian subjects?
The Ser447-Ter mutation in lipoprotein lipase is associated with lower triglyceride and VLDL levels but does not significantly differ in frequency between patients with premature CAD and controls.
Zhang et al. (1995) studied this question.
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