Why the study?
Is the Ser447stop mutation in the LPL gene associated with elevated HDL cholesterol levels in healthy normolipidemic men?
Population
Healthy Dutch men with low-, middle-, and upper-decile HDL cholesterol (normolipidemic)
Comparison
Presence of the Ser447stop mutation in the… vs Absence of the mutation (wild-type LPL)
Design
Cross-sectional
Authors
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Supports LPL Ser447stop association with high HDL in healthy men; leaves open CV benefit and clinical utility.
Is the Ser447stop mutation in the LPL gene associated with elevated HDL cholesterol levels in healthy normolipidemic men?
The Ser447stop mutation in the LPL gene is associated with increased HDL cholesterol in healthy men, which may confer a protective cardiovascular benefit.
Kuivenhoven et al. (1997) studied this question.
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