Why the study?
Does the PvuII polymorphism of the LPL gene associate with the risk and pathophysiology of Alzheimer's disease?
Population
395 autopsy-confirmed patients (242 controls, 153 Alzheimer's disease) from the eastern Canadian population
Comparison
PvuII single nucleotide polymorphism of the… vs Other LPL genotypes
Design
Case-control
Authors
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Supports LPL PvuII as AD candidate gene; hypothesis-generating and should not yet inform risk assessment or practice.
Does the PvuII polymorphism of the LPL gene associate with the risk and pathophysiology of Alzheimer's disease?
A common polymorphism in the LPL gene is associated with an increased risk of sporadic Alzheimer's disease and modulates brain pathophysiology.
Blain et al. (2006) studied this question.
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