May 7, 2024Frontiers in Cell and Developmental BiologyOpen Access

Τ cell-mediated adaptive immunity in the transition from metabolic dysfunction-associated steatohepatitis to hepatocellular carcinoma

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Authors

GPGrigorios PapadopoulosNational and Kapodistrian University of Athens EGEirini GiannousiNational and Kapodistrian University of Athens AAAikaterini P. AvdiNational and Kapodistrian University of Athens

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Implication

Review reveals adaptive immune dynamics during steatohepatitis progression to hepatocellular carcinoma in fatty liver disease, highlighting mechanistic targets for clinical stratification.

Key Points

Adaptive immunity mediated by T cells critically regulates the pathogenic transition from steatohepatitis to hepatocellular carcinoma in fatty liver disease.
Preclinical animal models and human biopsy analyses demonstrate that defining T cell metabolic signatures and dynamics is vital to map the hepatic immune niche.
Highlights that mapping specific T cell populations may enable biomarker discovery and patient stratification, though animal models require translational validation.

Cite This Study

Papadopoulos et al. (2024) studied this question.

synapsesocial.com/papers/68e6b291b6db643587633da9 https://doi.org/10.3389/fcell.2024.1343806

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Implication

Review reveals adaptive immune dynamics during steatohepatitis progression to hepatocellular carcinoma in fatty liver disease, highlighting mechanistic targets for clinical stratification.

Τ cell-mediated adaptive immunity in the transition from metabolic dysfunction-associated steatohepatitis to hepatocellular carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Τ cell-mediated adaptive immunity in the transition from metabolic dysfunction-associated steatohepatitis to hepatocellular carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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