Abstract Objective A two-sample Mendelian randomization method was used to study the causal relationship between Type 2 diabetes and post-herpetic neuralgia (PHN). Method Genome-wide association statistics of type 2 diabetes with PHN were obtained, and single nucleotide polymorphisms (SNPs) strongly associated with type 2 diabetes were used as instrumental variables(IVS).TSMR method with inverse variance weighting (IVW) as the primary analytical approach to evaluate the causal association between type 2 diabetes and PHN. Sensitivity analysis was also conducted to evaluate the strength and reliability of the findings. Results 39 SNPs strongly associated with type 2 diabetes were included in the analysis, which showed that type 2 diabetes was significantly associated with PHN(IVW: OR=1.508,95%CI=1.003-2.267), P=0.04). Sensitivity analyses demonstrated the strength and reliability of the causal relationship. Conclusion There was a correlation between type 2 diabetes and PHN, and type 2 diabetes was linked to a higher risk of PHN.
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ZHANG et al. (2024) studied this question.
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