Induction effect of antiretroviral bictegravir on the expression of Abcb1, Abcg2 and Abcc1 genes associated with P-gp, BCRP and MRP1 transporters present in rat peripheral blood mononuclear cells

Background Antiretrovirals have the potential to cause drug interactions leading to inefficacyor toxicity via activation of efflux transporters through nuclear receptors,altering drug concentrations at their target sites.