Comparative Study of the Effects of Clonidine and Tranexamic Acid on Intraoperative Bleeding in Rhinoplasty: A Clinical Trial

IntroductionThe present study was conducted to compare the effects of clonidine and tranexamic acid on the volume of bleeding and the quality of the surgical field in terms of bleeding in candidates for rhinoplasty surgery.MethodsIn this two-sided clinical trial, eligible candidates for rhinoplasty surgery were randomly assigned to two treatment groups: tranexamic acid and clonidine. The first group received tranexamic acid at a dose of 700 μg/kg of body weight two hours before the surgical procedure, while the second group received clonidine orally at a dose of two mg/kg of body weight 90 minutes before the surgery. Subsequently, the volume of bleeding was calculated based on the amount of blood collected in the suction and blood-soaked gauze, which had been previously weighed.ResultsOf 92 patients undergoing rhinoplasty surgery, 82%, were female. The mean age and standard deviation (SD) of individuals undergoing rhinoplasty surgery were 29.22 ± 8.50 years. There were no significant differences between the two treatment groups in age, gender, and body mass index. The volume of blood present in the suction during rhinoplasty surgery, categorized into surgery duration less than 63 min and 63 min or more, showed a significant difference between the two treatment groups of clonidine and tranexamic.ConclusionThe use of tranexamic acid, compared to clonidine, resulted in less intraoperative bleeding and a better surgical field. Due to the superior effectiveness of tranexamic acid in reducing intraoperative bleeding, it is recommended to use tranexamic acid instead of clonidine in rhinoplasty surgery.