Ceftaroline in CNS and ocular infections: a case series

Background There are limited data describing outcomes of patients treated with ceftaroline for infections with CNS or ocular involvement. Objectives To describe outcomes of patients treated with ceftaroline for methicillin-resistant staphylococcal infections involving the CNS or eye. Patients and methods This was a retrospective review of 10 patients at an academic medical centre who received ceftaroline for CNS or ocular infections. Results All patients were treated with ceftaroline as part of a combination for salvage therapy. Four patients died, whereas six patients experienced clinical cure. Only one experienced microbiological recurrence. Conclusions These preliminary data suggest that ceftaroline may be an option for salvage therapy of severe staphylococcal infections when used in combination.