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May 6, 2024Open Access

FIGURE 4 from LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency

Aditya Kulkarni Jianli Zhou Neha Biyani Umesh Kathad Partha P. Banerjee Shiv Srivastava Zsombor Prucsi Kamil Solarczyk Kishor Bhatia Reginald B. Ewesuedo Panna Sharma

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Abstract

LP-184 is effective in HRD TNBC PDX models regardless of their sensitivity to PARPi. LP-184 treatment (4 mg/kg i.v.) on days 0, 2, 4, 6, 8 and 16, 18, 20, 22, 24 in HRD TNBC PDX models showing HBCx-24 (PARPi resistant) tumor growth curves (mean ± SD) for vehicle versus treatment arms (A), T168 (PARPi sensitive) tumor growth curves (mean ± SD) for vehicle versus treatment arms (B), and Waterfall plot illustrating tumor regression in all 10 LP-184–treated PDX models (C).

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Cite This Study

Kulkarni et al. (2024) studied this question.

synapsesocial.com/papers/68e6b6d8b6db643587637890 https://doi.org/10.1158/2767-9764.25757549.v1

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S4 from LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency2024
2Supplementary Figure S4 from LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency2024
3FIGURE 6 from LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency2024
4FIGURE 2 from LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency2024
5Supplementary Figure S5 from LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency2024

Supplementary Figure S5 from LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency2024
TABLE 1 from LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency2024
TABLE 1 from LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency2024