Magnetic MIL‐101(Cr)‐NH₂ nanocomposite for extraction of nine parabens from chili powder and facial toner using LC–MS/MS

Parabens are frequently used preservatives in food and personal care products. These are also termed endocrine disruptors which have the potential to damage the endocrine system Therefore, an easy and facile extraction and detection of parabens are critically important. This work evaluates different magnetic sorbents such as Fe 3 O 4 @MIL‐101(Cr), Fe 3 O 4 @MIL‐101(Cr)@NH 2 , and Fe 3 O 4 @MIL‐101(Cr)@SO 3 H for magnetic solid phase extraction (MSPE) and further selected Fe 3 O 4 @MIL‐101(Cr)@NH 2 to determine paraben content in chili powder and facial toner samples. Fe 3 O 4 @MIL‐101(Cr)@NH 2 is an efficient sorbent material specially designed for MSPE, which profoundly extracted nine parabens within a short span of just 6 min, driven by π–π interaction and hydrogen bonding. And a detailed optimization and LC–MS/MS analysis was carried out. Fe 3 O 4 @MIL‐101(Cr)@NH 2 exhibited superior extraction efficiency, enabling subsequent quantification via LC–MS/MS. The limit of detection ranged from 0.063 to 0.622 ng mL −1 and limit of quantification of 0.211 to 2.073 ng mL −1 were a good recovery in the range of 76.2%–108%. An effective detection of eight parabens in chili powder and four parabens in facial toner samples was determined indicating that Fe 3 O 4 @MIL‐101(Cr)‐NH 2 sorbents are suitable for MSPE.