Present status of scheduled vaccinations and vaccination‐related bleeding in Chinese children with haemophilia

Aim Many countries have detailed recommendations for haemophilia patients to reduce the risk of vaccination‐related bleeding. However, data from developing countries are lacking. We investigated scheduled vaccinations and vaccination‐related bleeding complications in Chinese children with haemophilia and analysed issues related to vaccinations. Methods Children with haemophilia in the PUMCH Haemophilia Treatment Centre were contacted via telephone. We distributed a vaccination questionnaire to their parents. The severity of haemophilia, coagulation factor infusions before vaccination, injection mode, and vaccination‐related complications were analysed. Results A total of 440 valid questionnaires were received from 27 of 34 provinces in China. 31.3% (138/440) of the children with haemophilia did not receive all of their vaccinations. Among the children who received vaccinations, 48.1% (197/409) experienced bleeding complications. In patients with severe haemophilia, those on regular prophylaxis had a lower incidence of local hematoma compared to those on intermittent or no prophylaxis (14.3% vs. 26.5% vs. 39.7%, P < 0.05). The incidence of local hematomas was lower by subcutaneous (SQ) injections than by intramuscular injections (24.6% vs. 35.3%, P < 0.05). Conclusion The vaccination rate is quite insufficient in Chinese children with haemophilia. Missed vaccinations are related to vaccination‐related bleeding complications. Prophylaxis before vaccination and SQ injections would help reduce bleeding complications.