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October 8, 2025Journal of Antimicrobial Chemotherapy

Global susceptibility profiles and potential resistance mechanisms of ceftazidime–avibactam-resistant, non-carbapenemase-producing carbapenem-resistant Enterobacterales: 2020–23 data from the Antimicrobial Testing Leadership and Surveillance

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Authors

CLChih‐Cheng LaiCLChia‐Ying LiuKHKang Huang

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Overview

Observational analysis reveals high non-susceptibility rates in carbapenem-resistant Enterobacterales, suggesting alternative antibiotics are necessary.

Key Points

  • In vitro susceptibility rates for aztreonam–avibactam and colistin exceeded 86%, while amikacin and meropenem–vaborbactam showed poor performance.
  • Non-susceptibility rates for amikacin and meropenem–vaborbactam were 78.7% and 94.8%, regardless of region, infection source or species.
  • The prevalence of blaCTX-M-15 was closely correlated with amikacin non-susceptibility rates across Klebsiella pneumoniae and Escherichia coli.
  • High levels of ceftazidime–avibactam-resistant Enterobacterales necessitate investigations for effective antibiotic treatments.

Cite This Study

Lai et al. (2025) studied this question.

synapsesocial.com/papers/68e6bc5f38ca8e474d549d3ehttps://doi.org/10.1093/jac/dkaf375
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