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October 8, 2025Journal of Antimicrobial ChemotherapyOpen Access

Frailty Index Laboratory (FI-Lab) as predictor of poor outcomes for intra-hospital multidrug-resistant Klebsiella pneumoniae bloodstream infections: a single-centre retrospective cohort study

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Authors

CPCarmen PellegrinoNVNicola VeroneseLSLaura De Santis

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Overview

Retrospective cohort study evaluated FI-Lab's predictive ability for mortality and relapse in patients with CR-Kp BSIs, suggesting improved clinical decision-making.

Key Points

  • FI-Lab showed excellent predictive accuracy for mortality, with an AUC of 0.94.
  • Among 182 patients with CR-Kp BSIs, 48 died, showing a 26.3% mortality rate.
  • Each 0.10-point FI-Lab increase raised mortality risk by an HR of 2.07, indicating strong predictive power.
  • Further studies are needed to validate the FI-Lab's applicability in managing infections in fragile populations.

Cite This Study

Pellegrino et al. (2025) studied this question.

synapsesocial.com/papers/68e6bc5f38ca8e474d549d50https://doi.org/10.1093/jac/dkaf359
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