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May 25, 2026Experimental GerontologyOpen Access

Correlation between the frailty index derived from laboratory tests and 4-week all-cause mortality in critically ill patients with pneumonia

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Authors

YLYingying LuSCSong ChenJWJian Wan

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Overview

Retrospective analysis finds laboratory-based frailty index predicts mortality risk in critically ill patients, suggesting an efficient assessment tool.

Key Points

  • To determine the association between the laboratory-based frailty index and 28-day all-cause mortality in ICU patients with pneumonia.
  • Retrospective analysis of 9229 patients from MIMIC-IV database
  • Patients were assessed using Lab-FI based on 33 laboratory/vital sign variables
  • Statistical analyses included Cox proportional hazards models and propensity score matching.
  • 2416 patients died within 28 days, with higher Lab-FI scores associated with increased mortality (HR: 1.14; 95% CI: 1.09-1.18, p < 0.001)
  • Mortality risk was progressively higher across quartiles (Q2-Q4 vs. Q1, p < 0.001 for trend)
  • Age and cerebrovascular disease were significant effect modifiers (interaction p < 0.05).

Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a13e7430e02ee3982d31f6fhttps://doi.org/10.1016/j.exger.2026.113179
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