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May 31, 2026MedicineOpen Access

Laboratory frailty index and in-hospital mortality in ARDS: A retrospective cohort study

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Authors

JHJiaqi HuangJDJialiang DuXZXinxing Zhang

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Overview

Retrospective cohort study explores the link between laboratory frailty index and ARDS outcomes, suggesting clinical implications.

Key Points

  • This study investigates the relationship between a laboratory-based frailty index at ICU admission and in-hospital mortality in ARDS patients.
  • Retrospective cohort study using MIMIC-IV v3.1 database
  • Laboratory frailty index calculated from routine tests and vital signs at ICU admission
  • Multivariable logistic regression and survival analysis using Kaplan-Meier and Cox models applied.
  • Among 859 ARDS patients, 332 (38.6%) experienced in-hospital death.
  • Non-survivors had a higher frailty index (0.59) compared to survivors (0.54, P < .001).
  • FI-Lab independently associated with mortality (OR 1.26 per 0.1 increase; 95% CI 1.14–1.40; P = .003).

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd0df5783ba022b6fc824https://doi.org/10.1097/md.0000000000049147
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