Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 8, 2025Open Access

Evaluating Prompt Engineering Techniques for Accuracy and Confidence Elicitation in Medical LLMs

View Full Paper
Ask AI
Bookmark
Share

Authors

NNNariman NaderiZAZahra AtfPLPeter Lewis

Discussion

Loading...

Member takes

Overview

This analysis reveals how different prompt engineering techniques affect accuracy and confidence in medical contexts, highlighting the challenge of calibration.

Key Points

  • Chain-of-Thought prompts improved accuracy but increased overconfidence, leading to potential misjudgments in medical settings.
  • Five large language models were evaluated across 156 configurations, utilizing various prompt styles and confidence scales, revealing the need for careful calibration.
  • Calibrating confidence is essential, as emotional prompts inflating confidence can risk poor decisions in high-stakes medical tasks.
  • Smaller models like Llama-3.1-8b consistently underperformed, while proprietary models showed higher accuracy but still needed calibrated confidence.

Cite This Study

Naderi et al. (2025) studied this question.

synapsesocial.com/papers/68e6bc5f38ca8e474d549e8bhttps://doi.org/10.48550/arxiv.2506.00072
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of large language models as a diagnostic tool for medical learners and clinicians using advanced prompting techniques2025 · 10 citations
  2. 2Impact of prompt engineering on large language models for risk of bias assessment: a comparative study2026
  3. 3Prompt Engineering Strategies for Generating Medical Case-Based MCQs with Large Language Models: A Multi-Model Comparative Study2026 · 4 citations
  4. 4Prompt engineering in consistency and reliability with the evidence-based guideline for LLMs2024 · 383 citations
  5. 5Calibration of Self-Reported Confidence and Accuracy of Large Language Models in Medical Question Answering2026 · 2 citations