Efficacy of EGFR Targeting IR700-Related Photoimmunotherapy in Preventing Growth of Cancer Cells-A Systematic Review.

Research of Near-Infrared Photoimmunotherapy (NIR-PIT) related to human epidermal growth factor receptor (EGFR) in cancer is very popular in recent years. By destroying the cell membrane, NIR-PIT can kill cancer cells and prevent tumor development. By using a statistical method, our study aims to find out the suitable indices for evaluating the efficacy of EGFR-targeted NIR-PIT. Exploring strategy: (mice OR vivo study OR animal model) AND (NIR-PIT OR near-infrared photoimmunotherapy OR photoimmunotherapy) AND (EGFR OR EGFR receptor) AND (cancer OR tumor). Including standard: ① Reports could obtain full text from 2014 to 2024. ② Reports using tumor volume as an index of outcome. ③ Reports using IR-700, NIR-PIT, and EGFR antigens. The exclusion criteria were as follows: ① Reports could not obtain the full text. ② Reports that did not use the index above. ③ Reports that did not use IR-700, NIR-PIT, or EGFR antigens. ④ Reports could not obtain concrete data from articles. Using the above standards, we finally acquired 20 articles that conformed to requests. In this analysis, tumor volume showed statistical meaning of differentiation between experimental and control groups. However, 50% survival did not show the statistical meaning in the analysis. Through analysis, we found that the NIR-PIT groups had obvious differences compared with the control groups in tumor volume. However, we did not find any difference in the survival rates between NIR-PIT and control groups. This may be due to the following reasons: ① the number of samples was insufficient. ② Other indices of survival rate were more suitable in this study than 50% survival rate. Compared with 50% survival rate, tumor volume may be better for evaluating the efficacy of NIR-PIT.