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May 2, 2024Molecular Cancer Therapeutics

Bruton Tyrosine Kinase Degraders in B-Cell Malignancies

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Authors

THT. N. HuynhSRSonia Rodriguez‐RodriguezADAlexey V. Danilov

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Cite This Study

Huynh et al. (2024) studied this question.

synapsesocial.com/papers/68e6bd3bb6db64358763d7dfhttps://doi.org/10.1158/1535-7163.mct-23-0520
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract IA006: Resistance to BTK degraders2026
  2. 2Diverse signaling and vulnerabilities accompany distinct BTK mutations associated with clinical resistance to COVALENT, non-COVALENT and protacs targeting BTK in MYD88 mutated lymphomas.2025 · 1 citations
  3. 3Abstract 6069: Discovery and preclinical development of orally bioavailable potent BTK degrader, and its early clinical development for the treatment of relapsed and refractory B-cell malignancies2024
  4. 4Discovery ofHighly Potent and Selective, Orally BioavailableBTK-Targeting PROTACs Featuring Novel CRBN-Binding Warheads2026
  5. 5Abstract IA004: Targeting BTK in CLL and other B-cell Malignancies: Continuous Progress with a Continuous Therapy2026