Supplementary Figure S4 from Combination of an Autoantibody Panel and Alpha-Fetoprotein for Early Detection of Hepatitis B Virus-Associated Hepatocellular Carcinoma

Supplementary Figure S4: These four candidate TAAbs were further confirmed by indirect ELISA with two testing cohorts. In the initial verification of candidate TAAbs in 120 sera, the expression of all four TAAbs was significantly different between the HBV-HCC and CHB groups (P<0.001) (Supplementary Figure S4A). These four TAAbs were further validated in a large dataset (663 sera). The results showed that the expression of four TAAbs was significantly different in the pairwise comparisons between the three groups (P<0.01), and the expression was highest in the HBV-HCC group and lowest in the CHB group (Supplementary Figure S4B).