Supplementary Figure S4 from Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer

Supplementary Figure S4. A. Elbow plot showing optimal number of RCNs (k=7) for grouping cellular neighborhoods. B. Bar chart showing the number of cells assigned to each of the seven RCNs across all αCD40 IA regions. C. Bar chart showing the percentage (out of 100) of cells assigned to each of the seven RCNs across all αCD40 IA regions. D. Stacked bar chart showing fraction (out of 1.0) of RCNs present per αCD40 IA region. E. Stacked bar chart showing average proportion (out of 1.0) of RCNs present in IA regions for eachαCD40-treated patient. F. Scatterplot reconstructions for each αCD40 IA region. Each dot represents a cell present in the IA, and each cell is colored by its original cell state phenotype (top scatterplot) or RCN assignment (bottom scatterplot).