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Introduction: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is considered the most advanced temporary life support which provides complete hemodynamic support in addition to gas exchange. There is limited data available on the impact of hyperlipidemia (HLD) on VA-ECMO patients. We sought to examine the national inpatient sample (NIS) database to describe in-hospital outcomes among these patients. Methods: The NIS was searched for hospitalizations of adult VA-ECMO patients with and without a concomitant diagnosis of HLD for the years 2019 and 2020. The primary outcome was inpatient mortality. Results: This study included 3,885 VA-ECMO patients, of which 1,082 (27.8%) patients had HLD. VA-ECMO patients with HLD had higher prevalence of hypertension (57.3% vs. 71.4%, p <0.001), and chronic kidney disease (26.3% vs. 17.0 %, p <0.001) compared to VA-ECMO patients without HLD. In-hospital mortality was higher among those with HLD (61.5 % vs. 45.5%, p <0.001). Multivariate regression showed that VA-ECMO patients with HLD had higher inpatient mortality (OR 1.371, 95% CI 1.332-1.410, p <0.001). On secondary analysis, patients had higher odds of having ventricular arrhythmia (OR 1.472, 95% CI 1.416-1.531, p <0.001), acute kidney failure (OR 1.394, 95% CI 1.359-1.429, p <0.001), intracranial hemorrhage (OR 1.157, 95% CI 1.099-1.219, p <0.001), DVT (OR 1.252, 95% CI 1.200-1.306, p < 0.001), and sepsis (OR 1.226, 95% CI 1.195-1.257, p <0.001) compared to VA-ECMO patients without HLD. Conclusion: In this nationally representative population‐based retrospective cohort study, HLD was associated with higher mortality and worse outcomes among VA-ECMO patients.
Pastore et al. (Thu,) studied this question.