May 1, 2024BrainOpen Access

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy

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Authors

CBCarolin BöingUniversity of Basel MFMarta Di FabrizioÉcole Polytechnique Fédérale de Lausanne DBDomenic BurgerÉcole Polytechnique Fédérale de Lausanne

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Implication

Correlative microscopy analysis reveals distinct alpha-synuclein inclusions across glial and neuronal cells in multiple system atrophy donors, highlighting cell-specific pathways in pathology.

Key Points

Alpha-synuclein forms distinct inclusions across oligodendrocytes, neurons, and dark cells, with fibrillar glial cytoplasmic inclusions enriched in lysosomes and peroxisomes.
Correlative light and electron microscopy was employed to examine post-mortem substantia nigra and putamen tissues from donors diagnosed with multiple system atrophy.
Highlights an intricate multicellular interplay and implicates the autophagy pathway alongside dark microglia in the origin or spread of pathological alpha-synuclein aggregates.

Cite This Study

Böing et al. (2024) studied this question.

synapsesocial.com/papers/68e6c033b6db64358763f7a3 https://doi.org/10.1093/brain/awae137

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Implication

Correlative microscopy analysis reveals distinct alpha-synuclein inclusions across glial and neuronal cells in multiple system atrophy donors, highlighting cell-specific pathways in pathology.

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy

Discussion

Member takes

Implication

Key Points

Cite This Study

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy

Discussion

Member takes

Implication

Key Points

Cite This Study

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