The first asymmetric Mannich reaction of α-aminomaleimides with N-Boc imines was successfully performed using 5 mol% of a urea-type organocatalyst derived from quinine to afford the corresponding Mannich adducts in high yields with high enantioselectivities. This protocol has a simple experimental procedure, good functional group tolerance, broad substrate scope, and high enantioselectivities.
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Suzuki et al. (2024) studied this question.
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