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Laboratory analysis explores TMEM63B channel expression in the mouse urinary tract, suggesting a role in sensing mechanical shear stress.
The epithelial cells that line the kidneys and lower urinary tract are exposed to mechanical forces including shear stress and wall tension; however, the mechanosensors that detect and respond to these stimuli remain obscure. Candidates include the OSCA/TMEM63 family of ion channels, which can function as mechanosensors and osmosensors. Using Tmem63b
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Dalghi et al. (2024) studied this question.
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